| abstract |
Compounds according formula (I)n A-G-Z-W nand pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, n A is (C 6 -C 10 )aryl, (C 6 -C 10 )aryl-SO 2 , (C 6 -C 10 )aryl-CH 2 -, (C 6 -C 10 )arylcarbonyl, (C 1 -C 9 )heteroaryl,n(C 1 -C 9 )heteroaryl-SO 2 -, (C 1 -C 9 )heteroaryl-CH 2 -; or (C 1 -C 9 )heteroarylcarbonyl; n G is selected from the group consisting of:n nwhere B is (C 6 -C 10 )aryl or (C 1 -C 9 )heteroaryl, and X is CH 2 , SO 2 , or carbonyl;n nwhere X is CH 2 , SO 2 , or carbonyl; and R 1 and R 1' are each independently selected from H,nCN, (C 1- C 8 )alkyl-, and phenyl(CH 2 )-, wherein said alkyl and phenyl groups are optionallynsubstituted; andn nwhere Z and W are as defined in the present Specificiation; and pharmaceutical compositionsnand methods useful to increase secretion of growth hormone(GH) from the anterior pituitary ofnmammals, including on a sustained release basis. |