http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1149098-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e61cfb51fa2b44c437821e74916283f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1999-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_000ba5933cf3c93d526e3bc3e88cafac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cae658014318d62c8e450ccd21c8792b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ec48064547b86b2399fca934e48653c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7bd6b104a0e6b39fc3e9bc9cb0ce2cf |
| publicationDate | 2001-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1149098-A1 |
| titleOfInvention | An improved process for the preparation of 7-azaindolyl-3-carboxylic acid |
| abstract | A process for the preparation of 7-azaindolyl-3-carboxylic acid is described starting from succinonitrile (VIII) which is condensed with ethyl formate and the so formed salt of 2-hydroxymethylenebutyrronitrile (VII) is reacted with tert.butylamine to give N-tert.butylaminomethylene-succinonitrile (VI) which is reacted in a warm ambience in the presence of a base to give 1-tert.butyl-2-amino-4-cyanopyrrole (V) which is reacted with a malondialdehyde acetal to give 1-tert.butyl-3-cyano-7-azaindole (IV) which in a suitable solvent is heated under reflux with a Lewis acid and the corresponding dichloroderivative (III), treated with a suitable proton donor, gives 3-cyano-7-azaindole (II) which is hydrolyzed at the temperature of 70 °C at pH 2.5 to provide 7-azaindolyl-3-carboxylic acid (I). |
| priorityDate | 1998-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.