| abstract |
The instant invention provides novel substitutednnaphthyl compounds, intermediates, compositions,npharmaceutical formulations, and methods of use. The novelnnaphthyl compounds have the formulan nwhereinn R 1 is -H, -OH, -O(C 1 -C 4 alkyl), -OCOAr where Ar isnphenyl or substituted phenyl, -O(CO)OAr where Ar is phenylnor substituted phenyl, -OCO(C 1 -C 6 alkyl), -O(CO)O(C 1 -C 6 nalkyl), or -OSO 2 (C 4 -C 6 alkyl); R 2 is -H, -F, -Cl, -OR, -O(C 1 -C 4 alkyl), -OCOAr wherenAr is phenyl or substituted phenyl, -O(CO)OAr where Ar isnphenyl or substituted phenyl, -OCO(C 1 -C 6 alkyl), -O(CO)O(C 1 -C 6 nalkyl), or -OSO 2 (C 4 -C 6 alkyl); R 3 and R 4 are, independently, -H, -F, -Cl, -CH 3 , -OH,n-O(C 1 -C 4 alkyl), -OCOAr where Ar is phenyl or substitutednphenyl, -OCO(C 1 -C 6 alkyl), -O(CO)O(C 1 -C 6 alkyl), orn-OSO 2 (C 4 -C 6 alkyl), with the proviso that both R 3 and R 4 ncannot be hydrogen; n is 2 or 3; and R 5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl,ndimethyl-1-pyrrolidinyl, 4-morpholino,ndimethylamino, diethylamino, or 1-hexamethyleneimino;nor a pharmaceutically acceptable salt or solvate thereof. |