| abstract |
An osmotic solid pharmaceutical formulation for the controlled diffusional and osmotic delivery of a therapeutic agent to an environment of use comprising: na core comprising a physical mixture of a sulfoalkyl ether cyclodextrin, a therapeutic agent and a pharmaceutically acceptable carrier; and na membrane surrounding said core and comprising a film forming agent and a pore forming agent, said membrane having a passageway therethrough for communicating said core to an environment of use; nwherein, na first portion of said therapeutic agent diffuses through said membrane and a second portion of said therapeutic agent passes through said passageway; and na major portion of said therapeutic agent is not complexed with said sulfoalkyl ether cyclodextrin. |