| abstract |
A compound of formula (I) in which R1 is lower alkyl, halogen, optionally substituted heterocyclic group or optionally substituted aryl, R2 is carboxy, protected carboxy or amidated carboxy, Ar is optionally substituted aryl or optionally substituted heterocyclic group, A is lower alkylene, X is oxa or a single bond, Y is thia, sulfinyl or sulfonyl, Z is methylene, thia, sulfinyl or sulfonyl, m and n are each an integer of 0 to 6, and 1≤m+n≤6, or its salt, which is useful as an inhibitor of matrix metalloproteinases (MMP) or tumor necrosis factor α (TNF α). |