| abstract |
The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R1 is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR9; Y is nitrogen or CR10; Q is nitrogen or CR11, provided that if Q is nitrogen then X is CR5 and Y is CR?10; R2 and R3¿ are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO¿2?-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R?4¿ is a rest (b) or (c); and R5 is hydrogen, C¿1?-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R?1, R2, R3, R4 and R5¿ have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist. |