http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1136554-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 2000-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_271bc20fd52ea113403b146f632a4bcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_064213c1125dd2ac9cdaf68dffe1e151 |
| publicationDate | 2001-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1136554-A1 |
| titleOfInvention | ATP binding cassette transporter 1 (ABC1) gene polymorphisms and uses thereof for the diagnosis and treatment of lipid disorders, cardiovascular diseases and inflammatory diseases |
| abstract | The present invention provides four common polymorphisms in the gene encodingnthe ATP-binding cassette transporter-1 ( ABC1 ), which are associated with decreasednApoA-I mediated efflux of cholesterol, the first step of reverse cholesterol transport.nThe provided data can be taken as evidence that common polymorphisms in ABC1 ndirectly affect cellular lipid homeostasis, which is a key factor in the atherogeneticnprocess. The frequencies of three of the common ABC1 variants are significantlynincreased in a population of men having low HDL-C levels and established CHDnrelative to CHD-free control subjects. The use of the provided ABC1 polymorphismsnfor the diagnosis and treatment of lipid disorders, cardiovascular diseases, andninflammatory diseases like psoriasis and lupus erythematodes is claimed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03057911-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004067774-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004067774-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03057911-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1978108-A3 |
| priorityDate | 2000-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.