| abstract |
A pharmaceutical composition for inhibiting COX-2 biosynthesisncomprising a therapeutically effective amount of the compound ofnformula I and a pharmaceutrically acceptable carrier.n nwhereinn R 1 and R 4 represent either Hydrogen or together a bond R 5 , R 6 , R 7 , R 8 represent independently of each other Hydrogen, Hydroxynor Methoxy; in addition R 7 represents a sugar substituentnlike glucoside, rutinosid, manno gluco pyransyl, aprosylglucoside R 2 and R 3 represent Hydrogen, Hydroxy, Methoxy orn nwherein R 2 ', R 3 ', R 4 ', R 5 ' and R 6 ' nare independently or each other Hydrogen, Hydroxy or Methoxy withnthe proviso, that R 2 or R 3 is represented by the optionally substitutednPhenylring. |