| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8aa51b666f0e0145a8dfa426d15acfe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bdf1e95bca93b152706e4ed188462190
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40262195b6fc4348fb20bf67410da094
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a69a48ca47b115fe524a3283f2fab549 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 |
| filingDate |
1999-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_684028af33df29e2a5938457cd17bbbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87446fa0b92d047153055cc4adce0112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40024f6efe2c05a22f496a8252b28de9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e04fdeee6a9a4c2299a854ff5aaf0d9 |
| publicationDate |
2001-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1124831-A2 |
| titleOfInvention |
Sodium salt of 3-(4-cinnamyl-1-piperazinyl)imino-methyl rifamycin sv and process of preparation |
| abstract |
Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamycin SV was synthesized. The compound shows high activity against Gram-positive and Gram-negative microorganims, Mycobacterium tuberculosis (including atypical and rifampicin resistant) and may be used in the medical practice. The sodium salt has formula (II). The process for preparation of the sodium salt consists of reacting equimolar quantities of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamycin SV and sodium ascorbate with addition of 30% methanol solution of sodium methylate, followed by filtration and removement of the solvent by distillation under reduced pressure. The compound can also be obtained from the sodium salt of 3-formil rifamycin SV, which is reacting with N1-amino-N4-cinnamypiperazin in medium of inert solvent at room temperature. |
| priorityDate |
1998-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |