| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70571
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90209 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70571
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate |
2001-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_183be2a8231e0e908a9f3f3cffe70b97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e041760a16980e4587b71a7a5a3da6e |
| publicationDate |
2001-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1120723-A2 |
| titleOfInvention |
Identification of the cytochrome P-450 inhibitory potency of neurokinin-1 receptor antagonists and associated pharmacophore models and screening methods |
| abstract |
The present invention relates to novel screening methods which enable thenselection of neurokinin-1 (NK-1) receptor antagonist compounds which do notnpossess significant inhibitory potency towards cytochrome P450 enzymes, innparticular, CYP2D6. The present invention also relates to a method of generating anpharmacophore model for the CYP2D6 inhibitory activity of NK-1 receptornantagonist compounds; to methods for the discovery of molecules that are potentialnNK-1 receptor antagonist compounds which do not possess significant inhibitorynpotency towards the CYP2D6 enzyme; to methods of modeling the features of thenCYP2D6 pharmacophore useful in selecting NK-1 receptor antagonist moleculesnwhich do not possess significant potency towards CYP2D6. Further, the inventionnalso relates to pharmaceutical compositions comprising a NK-1 receptor antagonistncompound which does not possess significant potency towards the CYP2D6 enzymenidentified by methods of the invention; to the uses of a NK-1 receptor antagonistncompound identified by the methods of the invention for the manufacture ofnmedicaments and for the treatment of a condition, a disorder or a disease in a mammalnfor which an NK-1 antagonist receptor compound identified by the method of theninvention is therapeutically useful. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108844917-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005121085-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108701171-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109559366-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7241798-B2 |
| priorityDate |
2000-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |