http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1117373-A1

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filingDate 1999-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8de9866a6318a6333efb37d0b21435e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0eb3ffa6c6b3c9238fd1315037aef86
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publicationDate 2001-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1117373-A1
titleOfInvention Hair tonic
abstract A hair-restoring or -loss-reducing agent contains one or more specified cyclic (e.g. benzene or pyridine) compounds or their physiologically-compatible salts. A hair-restoring or -loss-reducing agent contains one or more cyclic compounds of formula (I), (II) or (III) or their physiologically-compatible salts. A and B = CH or N, with at least one being CH; Y = -O-, -(CH2)n-, -NH-CH2-, -CH2-NH-, -N:N-, -CH:CH-, -CH2-O-, -O-CH2-, -N:CH-, -CH:N-, -(CH2-CH2-O)m- or -(O-CH2CH2)m; m and n = 1, 2, 3 or 4; Z = -NH-CH2-, -CH2-CH2-, -CH:CH- or -CH2-NH-; R1 = H, OH or 1-4C hydroxyalkyl; R2 = H, cyclopropyl or 1-4C alkyl; R3 = 1 or 2C hydroxyalkyl, -CH2X, -CHX2 (with X = Cl, Br, F or I), -COCH3, -CF3, -CH3 or a group of formula (IV) - (VII) : R = NO2, SO2CH3, CF3, CHF2, CH2F, F or Cl; R4 - R6 = NO2, SO2CH3, CF3, CHF2, CH2F, F, Cl, Br or H; R7 = -OH, -OSO3H, -O(1-4C alkyl), -CH2CH2OH, -CH2OH or 1-4C alkyl; and R8 = 1-6C alkyl or hydroxyalkyl, 2-6C hydroxyalkenyl, aryl, heteroaryl or 2-6C alkenyl carboxylic acid group An Independent claim is also included for the use of the following compounds in promoting hair-restoration or in reducing hair-loss: 1-(N-(2/-nitro-4/-trifluoromethyl-phenyl)-amino)-3-chloro-2-hydroxypropane; 1-(N-(2/-nitro-4/-trifluoromethyl-phenyl)-amino)-2-hydroxy-2-trifluoromethylethane; 1-(N-(2/-nitro-4/-trifluoromethyl-phenyl)-amino)-propane-2,3-diol (especially preferred);1-(2-nitro-4/-trifluoromethyl-phenyl)-1-butene-3,4-diol; 2,6-diamino-3-((pyridin-3-yl)-azo)-pyridine (especially preferred); and/or 2,6-diamino-3-((pyridin-3-yl)-azo)-pyridine-1-oxide.
priorityDate 1998-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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