http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1116718-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_977ebb660999f345084ffad260515ff6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 1996-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8779dfd2d2eafdadcd1f47335d4d4ac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b647fe318dc782d4faef78d6956fe1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd23c25ed8b3c3233abe63db36823ac2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8ea64efc26249f94441e3ecbed97c3d |
| publicationDate | 2001-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1116718-A2 |
| titleOfInvention | Method for the preparation of taxol and its derivatives |
| abstract | The invention refers to a process for the preparation ofncompounds of formula ( I )n nwhereinn R 1 is an aryl or heteroaryl group; R 2 is hydrogen, arylcarbonyl, heteroarylcarbonyl or C 1 -C 6 nalkoxycarbonyl; R 3 is hydrogen or acetyl; nthe process comprising reacting a compound of formula (II)n nwhereinn R 1 is as defined above, the symbol --- represents a single or andouble bond, R 7 is C 1 -C 6 alkoxycarbonyl, arylcarbonyl ornheteroarylcarbonyl, each of R 4 and R 5 independently isnhydrogen, C 1 -C 6 alkyl, C 1 -C 3 alkoxy, aryl or heteroaryl; and R 6 is C 1 -C 6 alkyl, aryl or heteroaryl, provided that whennthe symbol --- is a double bond, R 7 and R 4 do not exist and R 5 nis aryl or heteroaryl, with a compound of formula (III) n nwherein each of R 8 and R 9 independently is a hydroxy protectingngroup in the presence of a condensing agent so obtaining ancompound of formula (IV)n nwherein R 1 , R 4 , R 5 , R 7 , R 8 and R 9 , and the symbol --- are as definednabove, provided that when --- is a double bond R 7 and R 4 do notnexist and R 5 is aryl or heteroaryl, and deprotecting thencompound of formula (IV) under such condition so as to producenthe compound of formula (I), as defined above, and optionallyntransforming a compound of formula (I) into another compound ofnformula (I). n The compounds of formula (II) are also claimed. n The compounds of formula (I) are antitumoral compounds. |
| priorityDate | 1995-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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