| abstract |
This invention provides a compound of formula (I) and its pharmaceutically acceptable saltsn nwherein R is halo C 1 -C 8 alkyl, halo C 2 -C 8 alkenyl, halo C 2 -C 8 alkynyl or halo C 1 -C 8 alkylnsubstituted by hydroxy or C 1 -C 8 alkoxy; R 1 is hydrogen, halo or C 1 -C 6 alkoxy; or R and R 1 ,ntogether with two carbon atoms shared between the benzene ring and the R and R 1 , complete anfused C 4 -C 6 cycloakyl wherein one carbon atom is optionally replaced by oxygen andnwherein one or two of the carbon atoms are optionally substituted by up to five substituentsnselected from halo, C 1 -C 6 alkyl and halo C 1 -C 6 alkyl; X is C 1 -C 6 alkoxy, halo C 1 -C 6 alkoxy,nphenoxy or halo; and Ar is phenyl optionally substituted by halo. These compounds are ofnuse in treating a gastrointestinal disorder, a central nervous system (CNS) disorder, anninflammatory disease, emesis, urinary incontinence, pain, migraine, sunburn, diseases,ndisorders and adverse conditions caused by Helicobacter pylori or an angiogenesis especiallynCNS disorders in a mammalian subject, especially humans. |