| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e61263b84630539d1fc5281e3bd9ac4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-34 |
| filingDate |
1999-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96e98bee9735f631a55b642e9cfeec1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_375a140acaf04b52939dabf1493b3c47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69c8f3bb90cebb510bd39ca1a6658b91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b50e2e77cc6bf757bcb7801a0684782
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_210ac2fa31699478c57473e85a1dd3de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16b6e6a86a0092597cf7f8096daea4a0 |
| publicationDate |
2003-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1114047-B1 |
| titleOfInvention |
An improved process for the preparation of thiazolidine-2,4-dione derivatives |
| abstract |
An improved process for the preparation of 5-[4-[[3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione of formula (1) which comprises: reducing the compound of formula (2') where R represents a (C1-C4)alkyl group using Raney Nickel or Magnesium in alcohol having 1 to 4 carbon atoms or mixtures thereof, if desired reesterifying using sufphuric acid at a temperature in the range of 0° C. to 60° C. to obtain a compound of formula (3') wherein R is as defined above, hydrolyzing the compound of formula (3') wherein R is as defined above, by conventional methods to obtain the acid of formula (4), condensing the acid of formula (4) with N-methyl anthranilamide directly without any preactivation of the acid to produce the compound of formula (1) and if desired, converting the compound of formula (1) to pharmaceutically acceptable salts thereof by conventional methods. |
| priorityDate |
1998-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |