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filingDate 1999-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2001-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1104456-A1
titleOfInvention Engineered antigen-presenting cells expressing an array of antigens and uses thereof
abstract The present invention provides a method for presentation of multiple disease associated antigens in antigen-presenting cells which can be used to generate a prophylactic or therapeutic immune response against the disease with which the antigens are associated. The method employs differential screening of nucleic acid sequences expressed by target and non-target cells. By identifying nucleic acid sequences preferentially expressed in a target cell population and expressing the identified sequences in antigen-presenting cells, one can stimulate an immune response directed at a target cell population without being limited to single, previously identified antigens.
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