abstract |
A preparation capable of releasing a medicinal substancenat a targeted site in the intestine, wherein the preparation dose notnreleases medicinal substance in endogastri at all, but can quicklynrelease a medicinal substance when it reaches the desired site in thenintestine after a certain period of time from discharge of thenpreparation from the stomach, and wherein a core materialncontaining a medicinal substance is coated with a mixed film of anhydrophobic organic compound - an enteric polymer. n The preparation is useful for a local therapy ofninflammatory disease in the intestine such as ulcerative colitis ornCrohn's disease, or an oral administrative therapy with a medicinalnsubstance of a peptide which is apt to be decomposed chemically ornenzymatically in any site except for a specific site in the intestinensuch as the large intestine, or with a medicinal substance whosenabsorption site in the intestine is limited, or the like, because anmedicinal substance can be delivered selectively to a specific site innthe intestine. |