http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1100799-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2901e694724c2a759f619944cb7d2a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 |
| filingDate | 2000-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2814a1b3285e8a389bddc3ba2b74a22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb1fe242be1585ae73177a153028f60b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_352e6ac1fb8f82c30c8ef4bd9d881c5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e074e1041db3c591b1bfaa82a7113f95 |
| publicationDate | 2002-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1100799-B1 |
| titleOfInvention | Preparation of camptothecin and nothapodytine derivatives |
| abstract | The invention concerns the preparation of nothapodytine or camptothecin derivatives which consists in causing 4-ethyl 2methyl hepta-2,4-dienoic acid act on a 3-aminomethyl 2-bromo quinoline derivative (III) wherein R1 and R2 are H or R1 is a halogen atom or alkyl, R2 is a O-CO-X radical as defined for the camptothecin derivatives; or R1 and R2 are defined for the known camptothecin derivatives or represent protected radicals or radicals easily convertible into the radicals R1 and R2, to obtain the quinoline derivative (IV); adding to the resulting quinoline derivative (2-methoxy carbonyl vinyl) tributyltin in the presence of a complex of palladium and triphenylarsin to obtain the quinoline derivative (V); cyclizing the resulting quinoline derivative to obtain the tetracyclic derivative (VI); then in subjecting said derivative to an ozonolysis followed by treatment with dimethyl sulphide to obtain the tetracyclic derivative (VII); saponification followed by decarboxylation in oxidising conditions of the resulting tetracyclic derivative to obtain the nothopodytine derivative (VIII); then optionally transforming the resulting derivative into a camptothecin derivative or into a mappicine derivative. |
| priorityDate | 1999-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.