| abstract |
Antibodies to intracellular domains of two or more kinds of protein tyrosinenphosphatases, methods for generation thereof and cells producing these antibodies arendisclosed. The antibody of the present invention may have specificity to intracellularndomains of phosphatase subunits of both of LAR and CD45, and may be useful for analysisnand quantitative determination of PTPs, identification and detection of novel PTPs, and fornobtaining novel phosphatases by cloning and the like, as well as for developing usefulndiagnostic methods of insulin resistance and NIDDM, for prophylaxis and diagnosis ofnvarious disease states of syndrome X that is based on insulin resistance, and for prophylaxisnand diagnosis of onsets of arteriosclerosis and cardiac diseases. |