http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1095047-A4
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78941ed5a01bfbcd48376e1fdb485b19 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4065 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-201 |
filingDate | 2000-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6000125e3e900598b68f586c47075cc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8bb5c0fd5438e9def96710fd5d633d0 |
publicationDate | 2002-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-1095047-A4 |
titleOfInvention | PREPARATIONS OF THIOPHOSPHITES AND THIOPHOSPHONATES |
abstract | Improved methods for converting phosphite or phosphonate esters into corresponding thiophosphites or thiophosphonates and for synthesizing specific thiophosphite and thiophosphonate compounds so produced are disclosed and claimed. The methods start from phosphite diesters using P4S10 as the thionation reagent. The reaction mixture is refluxed until the reaction is complete and may be followed by separation and chloroformate ester phosphonation steps to produce pure thiophosphonocarboxylate triesters. Alternatively, these esters may be prepared directly by action of P4S10 on the corresponding phosphonocarboxylate esters. The former method was used to prepare dimethyl thiophosphite and thence trimethyl thiophosphonoformate, a key intermediate in synthesis of salts of thiophosphonoformic acid, which have anti-viral properties. |
priorityDate | 1999-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.