| abstract |
Novel compounds of formula (I)n nwhereinn n is 0 to 2; A is sulfur, CH 2 , oxygen, -NH- or selenium, provided that when n is 0, A cannot be CH 2 ,nand when n is 1, A cannot be CH 2 or NH; X is at least one substituted or unsubstituted C 1 -C 3 alkyl or alkenyl group, a C 2 -C 3 alkynyl group, a substituted or unsubstituted amino group, sulfur or oxygen; Ar is a substituted or unsubstituted monocyclic carbocyclic or heterocyclic ring or fusednor nonfuxed carbocyclic or heterocyclic ring system; and R 1 and R 2 are independently hydrogen or a moiety which forms a readily hydrolyzablenester group or a pharmaceutically acceptable salt thereof are found to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT). nA novel method of preparing such compounds is also disclosed, as well as methods andncompositions for employing the compounds as antiproliferative agents. |