| abstract |
The role of epsilon isozyme of protein kinase C ("PKC epsilon ") in pain perception, particularly hyperalgesia, methods of lessening pain through administration of inhibitors of PKC epsilon , methods of identifying compounds that modulate pain, uses of inhibitors of PKC epsilon in the preparation of a medicament for the treatment of pain, and pharmaceutical compositions comprising an inhibitor of PKC epsilon and PKC epsilon -independent analgesic agent are disclosed. |