| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2773a2aeb05b5eabdf9e74906a9c5076 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 |
| filingDate |
1999-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcb97a67f602334a5c6b6345886ff923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_deb8411ed7b767e515ec8c0e2d4dfc1e |
| publicationDate |
2004-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1090037-B1 |
| titleOfInvention |
Divalent antibody fragments conjugated to PEG |
| abstract |
Divalent antibody fragments are described, each of which has one or more interchain bridges containing a synthetic or naturally occurring polymer selected from a polyalkylene, polyakenylene, polyoxyalkylene or polysaccharide. Each bridge may be the residue of a homo- or heterobifunctional cross-linking reagent and serves to link two heavy chains in each antibody fragment via the sulphur atoms of cysteine residues present in the chains. Each fragment may be attached to one or more effector or reporter molecules, and is of use in therapy or diagnostics where it has markedly improved binding and/or pharmacokinetic properties when compared to other antibody fragments which have the same number and type of polymer molecules but in which the polymer molecules are randomly attached. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8993731-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9102728-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11401349-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691233-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9096668-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10752676-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9631015-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8614295-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8075889-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8486662-B2 |
| priorityDate |
1998-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |