| abstract |
This invention identified two domains of ESX, a member of the ETS transcription regulator family, that provide particularly effective targets useful in screening for ESX modulators. One of these domains, ESX exon 4 is a potent transactivator and can be used in constructs to up-or downregulate genes or cDNAs, particularly genes or cDNAs under the control of a promoter containing an Ets element. Another of these domains, exon 7, is capable of acetylation and the level of acetylation can be used in assays for abnormal ESX regulation. |