| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d42f684941d5b0617ca7764ebdff07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-6615
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-6615
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate |
1999-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18c1680c2ddf701d5688108ed5166e85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9082d009e175597987bcd9e872e48d48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee47bb309f67a5e8f792468d7ed1698f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88fe3b44edc4d11bf26ee4fd85d65ebe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6dbd4330f94d6714ab1b4f1f35d1785 |
| publicationDate |
2001-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1085878-A2 |
| titleOfInvention |
Use of aminosterol derivatives as chloride ionophores |
| abstract |
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride (Cl-) channel regulated by phosphorylation and intracellular nucleotides. CFTR is the major Cl- transport pathway in airway epithelial cells. The abnormal transepithelial Cl- transport and subsequent defective fluid transport caused by CF is a result of the genetic mutations of the gene coding for the CFTR protein. The present invention is directed to the novel use of ionophores as artificial Cl- transport pathways into CF epithelia to treat the defective Cl- and fluid transport. Ionophores and in particular, small molecule ionophores, represent a potential novel means of treating CF. The invention also includes using an ionophore to generate chloride secretion on intact monolayers of airway epithelia cells and other epithelia cells by administering an ionophore to a mammal. |
| priorityDate |
1998-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |