| abstract |
Cardiac failure remedies containing as the active ingredient indan derivatives represented by general formula (I) or medicinally acceptable salts thereof, wherein R1 is hydrogen, nitro, cyano, amino, C¿1?-C6 alkylcarbonylamino or the like; R?2 and R3¿ are each independently C¿1?-C6 alkyl or the like; R?4¿ is hydroxyl or C¿1?-C6 alkylcarbonyloxy, or alternatively R?4¿ together with R5 represents a bond or oxygen; R5 is hydrogen, or alternatively R5 together with R4 represents a bond or oxygen; R6 is hydrogen, hydroxyl, NR7R8 or the like; n is an integer of 0 to 4; X is C=O, CH¿2?, SO2 or NR?16¿; when X is C=O, CH¿2? or SO2, Y is NR?17¿, while when X is NR16, Y is C=O; when Y is NR17, Z is absent, while when Y is C=O, Z is NR18; and W is aryl, a lactam ring or the like. |