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filingDate 1999-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2005-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a314fc9c0e9c1a3f02d540911ea6386f
publicationDate 2005-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1083788-B1
titleOfInvention Transgenic fish carrying a bacteriophage-derived transgene construct for mutation detection
abstract The present invention provides transgenic fish whose somatic and germ cells contain a genomically integrated bacteriophage lambda-derived transgene construct. The transgene construct can include an excisable test nucleic acid sequence containing a heterologous mutation target nucleic acid sequence that is detectable via bioassay in a bacterial cell into which the test nucleic acid has been introduced. The frequency of mutations in the mutation target nucleic acid sequence following exposure of the transgenic fish to one or more potentially mutagenic agents can thus be evaluated.
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