| abstract |
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula: (T)xA-B-D-E-G wherein A is an aryl or heteroaryl ring; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0, 1, or 2; the group D represents (a), (b), (c) or (d); the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents (e), (f) or (g); and with the proviso that when G is (f), each of the substituent on E is an independent substituent; and include pharmaceutically acceptable salts threreof. |