| abstract |
The present invention provides a novel bioactivensubstance having an antiangiogenic effect. n The chemical compound represented by the formula (1):n n(wherein, R 1 represents hydrogen atom, aldehyde group or anlower acyl group, R 2 and R 3 are the same as or different fromneach other and represent hydrogen atom or a lower alkoxyngroup or are combined to represent oxygen atom, R 4 representsna lower alkyl group and R 5 represents hydrogen atom or a lowernalkyl group, provided that compounds in which R 1 is aldehydengroup, R 2 and R 3 are different from each other and are hydrogennatom or methoxy group, R 4 is ethyl group and R 5 is hydrogennatom are excluded), a salt thereof or a hydrate thereof wasnisolated from the culture broth of genus Streptomyces andnthe structure thereof was analyzed. |