| abstract |
Indolo [2,1-b] quinazolin-6,12-diones of the formula (1) in which R 1 to R 8 are independently selected from hydrogen atoms and pharmaceutically acceptable substituents, and pharmaceutically acceptable salts of compounds of the formula (1) for use in medicaments for inhibiting the transcription factor NF-kB and / or for inhibiting COX a preferential inhibitory effect on COX-2; Such drugs are suitable for use as anti-inflammatory, in particular anti-rheumatic agents for the treatment of inflammatory diseases, in particular of the rheumatic type and arthritis, as well as for the preventive or adjuvant treatment of cancer and Alzheimer's disease as well as for the preventive or adjunctive long-term medication against age-related complaints. |