| abstract |
The pharmaceutical use of novel compounds of formula I:n nwheren Z is a structure of formulan A-B is -C=CH- or -C(R 5 )-CH 2 -; X is S or NR 4 ; R 1 is H, halo, formyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy,nthienylmethyloxy, 4,5-dihydrothiazol-2-yl, cyano, nitro,ncarboxamido, trifluoromethyl or hydroxy; R 2 is H or halo; R 3 is H, C 1 -C 4 alkyl, (C 1 -C 4 alkylene)-aryl, orn-CH 2 -Y-NR 7 R 8 ; R 4 is H, C 1 -C 4 alkyl, C 1 -C 5 acyl, or phenylsulfonyl; R 5 is H or OH; R 6 is H or methyl; Y is -CH 2 - or -C(O)-; R 7 is pyridinyl; and R 8 is H or -C(O)-(C 3 -C 6 cycloalkyl); and pharmaceuticallynacceptable salts thereof. |