http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1074561-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c22c6d06e5563aee18cc3c610cfa6180 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2000-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc4abdaf54524422fc3422b5a104672d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d846573814567959bb78ea41dcf6d9db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4c45af64b6b4734a4ba51e00f785df4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_556d79e0b0df7e9e59070c8d464eb3c3 |
| publicationDate | 2001-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1074561-A2 |
| titleOfInvention | Analogues of lipopolysaccharide-binding protein (LBP)-derived peptides |
| abstract | This invention relates to analogues of peptides from an LPS-binding protein (LBP),nthat were obtained by a.a. replacements at selected sites of the native sequence andnwhich express vigorous inhibitory activity upon LPS-mediated cell activation, both innvitro and in vivo . These peptide analogues exhibit advantageous properties tonameliorate endotoxin-related disorders, specially the systemic inflammatorynresponse syndrome. These peptide analogues are derived from an amphipaticndomain with high density of positive charge amino acids. The present inventionndefine the importance of certain peptide sequences to assure the optimumnneutralizing activity and potency. These peptide analogues impaired LBP binding tonLPS and inhibit human leukocyte cytokine production induced by LPS. Additionally,nthese peptides protect Actinomycin D-sensitized mice from lethal doses of LPS. Thisninvention also includes the use of the inhibitory peptides and related molecules in thentreatment of endotoxin-associated disorders, pharmaceutical compositionsncontaining the peptide analogues and derivatives, diagnostic methods utilizing thenpeptides of the invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020176554-A1 |
| priorityDate | 1999-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.