| abstract |
The present invention provides compounds represented by general formula (1) wherein R1 is selected from H, OH, OR2 or halogen (F, Cl, Br, I); R2 is lower alkyl (C1 to C6); n is selected from 0, 1 or 2; X is CH or CH2; m is selected from 2, 3 or 4; Y is N or CH; Ar is aryl or heteroaryl, both optionally substituted; or pharmaceutically acceptable salts thereof, as well as methods and pharmaceutical compositions utilizing these compounds for the inhibition of serotonin uptake and the treatment of CNS disorders, particularly depression. |