abstract |
Compounds of formulae (IA) and (IB):n nwherein R 1 , R 2 , R 3 , Ar 1 and X are as defined above, are endothelin antagonists. The compounds arentherefore useful in the treatment of a variety of conditions mediated by endothelin, such asnrestenosis, renal failure and systemic and pulmonary hypertension. |