| abstract |
Novel indole derivatives represented by formula (I) or salts thereof,nwherein R 1 is aryl-substituted lower alkyl in which the aryl may be substitutednby at least one member selected among halogen atoms, aryls, heterocyclicngroups, aryl-substituted lower alkyls, aryl-substituted lower alkenyls, lowernhaloalkyls, (lower cycloalkyl)-substituted lower alkyloxys, (lowerncycloalkyloxy)-substituted lower alkyls, aryl-substituted lower alkynyls,naryloxy-substituted lower alkyls, aryl-substituted lower alkyloxys, lowernalkylthios, lower alkyloxys, and alkenyls; and R 2 is a lower alkyl, lowernalkenyl, aryl, or heterocyclic group optionally substituted by halogeno, lowernalkyl, lower alkenyl, or aryl. These compounds have a hypoglycemic activitynand a PDE5 inhibitory activity and are useful as a drug. |