| abstract |
The present invention provides cell lines expressing a recombinant heteromeric AMPA glutamatenreceptor, preferably a human heteromeric AMPA glutamate receptor, or a recombinant humannhomomeric AMPA glutamate receptor. The invention also provides methods for preparing saidncell lines. The invention furthermore pertains to the use of said cell lines for the identification ofnglutamate receptor agonists, antagonists or modulators and methods for the identification of saidnagonists, antagonists or modulators. The invention also provides pharmaceutical compositionsncomprising said agonists, antagonists or modulators. The invention furthermore is concerned withnthe use of agonists, antagonists or modulators in the manufacture of a medicament for thentreatment of neurological disorders. |