| abstract |
The present invention relates to compounds of the formula I,n nin which B, D, E, G, X, Y, Z, R 1 , R 2 and s have the meanings indicated in the claims,ntheir physiologically tolerable salts and their prodrugs. The compounds of thenformula I are valuable pharmacologically active compounds. They are vitronectinnreceptor antagonists and inhibitors of cell adhesion and are suitable for the therapynand prophylaxis of illnesses which are based on the interaction between vitronectinnreceptors and their ligands in cell-cell or cell-matrix interaction processes or whichncan be prevented, alleviated or cured by influencing such interactions. For example,nthey can be applied for inhibiting bone resorption by osteoclasts and thus for treatingnand preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferationnof cells of the vascular smooth musculature. The invention furthermore relates tonprocesses for the preparation of compounds of the formula I, their use, in particularnas active ingredients in pharmaceuticals, and pharmaceutical compositionsncomprising them. |