http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1064275-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a4783407e23a20dbe43d383a5d0fcb5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 |
| filingDate | 1999-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f410ef886190cbf3c647557aae55fa3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b0b228f3d668e4ac1fcf83ede6ab344 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad0a311f69129bf52b9cf7ce7b675629 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3464a6dfff06990da621142f42a5ae8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c1c9a4f764400c91c2e95e5f836d1c0 |
| publicationDate | 2002-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1064275-B1 |
| titleOfInvention | Process for producing simvastatin and/or its derivatives |
| abstract | Process for the preparation of a compound of formula (VI), comprising the steps of: reacting a compound of general formula (I) with a ring-opening agent to provide a compound having general formula (II); protecting the hydroxy groups of the thus formed compound (II) with a pre-determined protective agent in order to substantially retard the reactivity thereof and provide a compound having general formula (III) or (VII), wherein the protective agent retards the reactivity of compound (II) by replacing the hydrogen atom of at least one of the hydroxy groups thereof with a carbon terminated group, whereby, in the case of compound (III) at least one of R<3> and R<4> is not hydrogen; reacting compound (III) and/or (VII) with an alkylating agent of formula R<7>X to obtain a compound having formula (IV) or (VIII) respectively, wherein R<7> preferably represents a methyl or ethyl group and X represents a halide, preferably chlorine, bromine or iodine; hydrolyzing the protective groups R<3>, R<4> and R<5>, R<6> of compounds (IV) and (VIII) respectively to obtain a compound of formula (V); relactonizing compound (V) to yield compound (VI). |
| priorityDate | 1998-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.