http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1062364-B1
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0bb6db818f0c67efdde3038c80baaacf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6837 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 1999-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0f44b3db2f985163aa4a02897e99ed9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b4086d7dc30e25bed2fa32e0c9428f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd9e230576c2f4992ede062ed2029073 |
| publicationDate | 2005-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1062364-B1 |
| titleOfInvention | Qualitative differential screening |
| abstract | Method for identifying and/or cloning regions of nucleic acids that are differently spliced in two different physiological situations comprises hybridizing RNA originating from a test situation with cDNA originating from a reference situation and identifying and/or cloning nucleic acids corresponding to differential splicing. Independent claims are also included for the following: (1) a method for identifying and/or cloning regions of nucleic acids that are differently spliced in two different physiological situations A and B, comprising: (a) forming heteroduplexes in a liquid phase between mRNA originating from situation A and cDNA originating from situation B; (b) forming heteroduplexes in a liquid phase between mRNA originating from situation B and cDNA originating from situation A; and (c) identifying and/or cloning RNA regions that are not paired off in steps (a) and (b); (2) a method for identifying and/or cloning regions of nucleic acids that are differently spliced in two different physiological situations A and B, comprising: (a) forming heteroduplexes between mRNA originating from situation A and cDNA originating from situation B, where the mRNA or cDNA is immobilized on a support; (b) forming heteroduplexes between mRNA originating from situation B and cDNA originating from situation A, where the mRNA or cDNA is immobilized on a support; and (c) identifying and/or cloning RNA regions that are not paired off in steps (a) and (b); (3) a composition comprising nucleic acids identified and/or cloned by the above methods; (4) a nucleic acid composition comprising nucleic acids corresponding to alternative splicing that distinguishes two physiological situations of a cell or tissue; (5) libraries of nucleic acids or oligonucleotides specific for alternative splicing that distinguishes two physiological situations of a cell or tissue, or of microorganisms transformed with such nucleic acids; (6) a composition comprising a compound capable of interfering with the alternatively spliced products identified by the above methods. ACTIVITY : None given. MECHANISM OF ACTION : None given. |
| priorityDate | 1998-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 225.