| abstract |
The present Invention relates to a novel acetamide derivativenrepresented by the following Formula 1, which has an inhibitionnactivity for chymotrypsin type proteases and is usefull as anninhibitor for the above enzyme, especially as an inhibitor fornchymase, and the use thereof as a medicine, for example, annantiasthma drug or a drug for curing vascular injuriesncomplicated with angiogenesis and atheroma.n n wherein R 0 represents a substituted or unsubstitutednphenyl group, R 1 represents an aryl group, a heteroaryl or annaliphatic lower alkyl group with or without substituents, R 2 nrepresents a substituted or unsubstituted alkyl, an aryl alkyl,na heteroaryl alkyl, and a heteroaryloxy alkyl or the like, Jnrepresents a carbonyl group, or a methylene group or the like,nL represents a methoxy, hydroxyl or acetyloxy group or the like,nX and Y independently represents a nitrogen atom or a carbonnatom, Z represents a methylene group or a polyethylene groupnoptionally having a substituent. |