| abstract |
A process for preparing 2-phenyl-3-aminopyridine, and substituted phenyl derivativesnand salts thereof. A compound of the formulan n is reacted with a compound of the formulan n in a reaction inert solvent in the presence of a base and a palladium catalyst to obtainna compound of the formulan n Preferably, the compound of formula III or VIII is prepared by reacting a compound ofnthe formulan n with a compound of the formula n n orn ArCHO n in a reaction inert solvent. n The compound of formula V is preferably deprotected in aqueous acid to obtain a saltnof compound X. n X, Y, Z, Ar, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. |