http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1053021-B1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74487f7403edef60f9293ecb4f72065d |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2220-54 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12S3-14 |
filingDate | 1999-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2009-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_075ffc1aa36249dc116c3e914a9c36c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36c5debed7ed65f5da09f79058ad0fcd |
publicationDate | 2009-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-1053021-B1 |
titleOfInvention | Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media |
abstract | Removing free protein from a liquid mixture containing the protein and a protein-polysaccharide conjugate can be a technologically difficult, expensive, and time consuming process. The procedure described herein for removing the protein from such a mixture simplifies this removal. The procedure includes contacting the liquid mixture, including the protein and the protein-polysaccharide conjugate, with a solid phase, restricted-access media material. This material at least partially binds with the protein and separates it from the liquid mixture, thereby providing a purified liqid containing at least a portion of the protein-polysaccharide conjugate and a reduced amount of the protein. The purified liquid can be collected for further processing or use. As one example, the restricted-access media material can include porous silica particles that generally allow the protein to enter, but restrict or limit access to the protein-polysaccharide conjugate. In this manner, at least some of the free protein adheres, attaches, or otherwise binds to the restricted-access media material and separates from the conjugate. The process of the invention can be used for preparing protein-polysaccharide conjugates that can be used in vaccines or other pharmaceutical compositions. |
priorityDate | 1998-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.