abstract |
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN-, (where X and Y are hydrogen or various groups); R<SUP>a </SUP>represents alkylene; R<SUP>b </SUP>and R<SUP>c </SUP>each represents alkylene, the total number of carbon atoms in said straight chains of R<SUP>b </SUP>and R<SUP>c </SUP>being 7); R<SUP>2 </SUP>and R<SUP>3 </SUP>each represents hydrogen, or a group of formula R, RCO-, ROCO-, or RNHCO-, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R<SUP>1 </SUP>represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event. |