abstract |
The present invention provides novel purified and isolated nucleotidensequences encoding the cGMP-binding, cGMP-specific phosphodiesterasendesignated cGB-PDE. Also provided by the invention are methods andnmaterials for the recombinant production of cGB-PDE polypeptide productsnand methods for identifying compounds which modulate the enzymatic activitynof cGB-PDE polypeptides. |