http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1034182-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e14d6eb6e2b529693a4fd5c5238b4e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16322 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 1998-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98b27a159aed18109d4bff023e550670 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7672bf30fab5647cfff4af5ac50d563c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfaca9efd0ee7c3c38702f6a6c8be078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f778ae8da13d42960885e18e70a9f535 |
| publicationDate | 2000-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1034182-A1 |
| titleOfInvention | Inhibition of nuclear import by backbone cyclic peptide analogs |
| abstract | The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immunodeficiency virus type 1 proteins MA, Vpr, Tat and NLS-like sequences of HIV-1 protein Vif. We disclose the discovery of a novel, highly potent backbone cyclic peptide, designated BCvir, which inhibits nuclear import with an IC50 value of 35 nM. This inhibitory potency is to be compared to 12νM exhibited by the linear parent HIV-1 MA NLS peptide. BCvir also reduced HIV-1 production by 75 % in infected non-dividing cultured human T-cells and was relatively resistant to tryptic digestion. These properties render backbone cyclic peptide analogs of NLS or NLS-like sequences as candidates for novel drugs based on blocking nuclear import of viral genomes. |
| priorityDate | 1997-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.