| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee602c630e57f59c6cfc1c1634e36064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea5b64b3e78b7bf83fc591ddadd59ab1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85359c3b6af0a3cb85a2a3c18954cc4a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70571
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4756
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-43504 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57423
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43504 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate |
1998-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e84629cfdc13b71fcf94ce7f0c6ecbba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aff484a20e99e217fb189a8d83d0551e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcd3ba0686bf3da8a46ec8e6d884bf9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b99af0a6d0cccbcd68c3f85a806ca663
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c32b1ec1ef2fa35f39936e84c1e4040e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5732497a96994e69c1282fdb21ff02f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1da004dcae0a696199eb1a773fbdac39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5deb64bc075196d3c5b5438a5309ed60 |
| publicationDate |
2000-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1032588-A1 |
| titleOfInvention |
Interaction of alpha-conotoxin peptides with neuronal nicotinic acetylcholine receptors |
| abstract |
This invention relates to derivatives of the conopeptide MII, an α-4/7 conotoxin peptide, in which amino acid residues are substituted as described herein while maintaining the basic activity of MII. The present invention also relates to the discovery of the 3-dimensional structure of MII, and the relationship of its structure to its specificity to the α3β2 subtype of the neuronal nicotinic acetylcholine receptor (nAChR). The present invention also relates to computer based programs for the expression of the three-dimensional structure of MII and peptide analogs, peptide mimetics or non-peptide mimetics thereof. The structural characteristics may be correlated with biological activity to enable the design of α-4/7 conotoxin peptide analogs and peptide mimetics which demonstrate the same specificity to neuronal nAChR. Such analogs and peptide mimetics are useful as cardiovascular agents and for treating or detecting small-cell lung carcinoma (SCLC). |
| priorityDate |
1997-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |