| abstract |
A composition comprises a solid dispersionncomprising a low-solubility drug and at least onenpolymer. At least a major portion of the drug in thendispersion is amorphous. The polymer has a glassntransition temperature of at least 100°C measured at anrelative humidity of fifty percent. Another aspect ofnthe invention comprises the same composition except thatnthe dispersion has a glass transition temperature of atnleast 50°C at a relative humidity of fifty percent. Innanother aspect of the invention, a composition comprisesna solid dispersion comprising a low-solubility drug and anstabilizing polymer. At least a major portion of thendrug in the dispersion is amorphous. The compositionnalso includes a concentration-enhancing polymer thatnincreases the concentration of the drug in a usenenvironment. The stabilizing polymer has a glassntransition temperature that is greater than the glassntransition temperature of the concentration-enhancingnpolymer at a relative humidity of 50%. |