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filingDate 1998-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1027375-A1
titleOfInvention Anti-idiotypic monoclonal antibodies, their use in the active immunotherapy of malignant tumors, and compositions containing them
abstract Monoclonal anti-idiotype antibody which is specific for murine antibodies against gangliosides carrying N-glycolylated sialic acid particularly against those gangliosides which are expressed by tumoral cells. The monoclonal antibody is useful as immunomodulator for the treatment of cancer. Specifically, the monoclonal anti-idiotype antibody of the present invention is capable of inducing a response which is predominantly anti-idiotypic in xenogenic models. The monoclonal anti-idiotype antibody also exerts a protector effect against malignant tumors in animals
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