Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e1018b924ad1e238642eaad9d2172a7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-815 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-815 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
filingDate |
1997-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27ef820b107d6c94c1e19e17d1c707b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5343167c2ab97e82380d7921a54056b |
publicationDate |
2000-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1023324-A1 |
titleOfInvention |
Trivalent thrombin inhibitor |
abstract |
The present invention relates to a new thrombin inhibitor of formula (I) comprising an S subsite blocking segment (AS), an S' subsite blocking segment (Z), and a fibrinogen recognition exosite blocking segment (P). AS is linked to Z, which is linked to P according to the formula (1): AS-Z-P . The S' subsite blocking segment thus, besides binding to the thrombin S' subsites, connects the S subsite blocking segment and the fibrinogen recognition exosite blocking segment. This binding of Z segment together with the bindings of the AS and P segments, contributes to improve the affinity of the inhibitors significantly. |
priorityDate |
1997-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |