| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f4246e8fcebf17c365aced017a04c61 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0448
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-02 |
| filingDate |
1998-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75ff65ad9b96cfa84e1818f3e9713cef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_812cceb87b1fa8632487c1e6d5a15e90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c99332e4db71ad47735128c27f3d125b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38a19de5366b773ab9ad68a1f8c35d03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7f80185490d3863d4948b0e08b55d76 |
| publicationDate |
2000-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1023289-A1 |
| titleOfInvention |
Dopamine transporter imaging ligand |
| abstract |
The 3α isomer of RTI-55, RTI-352, is an effective in vivo binding ligand that reflects greater selectivity for the dopamine transporter than is observed with RTI-55. In addition, there is also a more rapid achievement of apparent equilibrium in the striatal-to-cerebellar ratio (compared to RTI-55) as the ratio peaks at about 30 min and is maintained for about 20 min thereafter. Such apparent equilibrium is useful in developing an approach to measuring the number of dopamine transporters present in tissues. Moreover, these results indicate that the utilization of 3α isomers of a variety of 3β (substituted phenyl) tropanes will result in greater selectivity for dopamine transporters and a more rapid of achievement of apparent equilibrium. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102006062061-A1 |
| priorityDate |
1997-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |