| abstract |
The present invention relates to new compounds for the inhibition of blood clottingnproteins, and more particularly, to arylalkanoyl derivatives of the formula I,n nwherein R(1), R(2), R(3), R(4), R(5), R(6a) and R(6b) have the meanings indicatednin the claims. The compounds of formula I are inhibitors of the blood clotting enzymenfactor Xa. The invention also relates to processes for the preparation of thencompounds of formula I, to methods of inhibiting factor Xa activity and of inhibitingnblood clotting, to the use of the compounds of formula I in the treatment andnprophylaxis of diseases, which can be treated or prevented by the inhibition of factornXa activity such as thromboembolic diseases, to and the use of the compounds ofnformula I in the preparation of medicaments to be applied in such diseases. Theninvention further relates to compositions containing a compound of formula I innadmixture or otherwise in association with an inert carrier, in particularnpharmaceutical compositions containing a compound of formula I together withnpharmaceutically acceptable carrier substances and auxiliary substances. |